摘要
目的研究间变性大细胞淋巴瘤（ALCL）的临床病理特征、免疫表型，以提高诊断水平。方法回顾性分析19例ALCL的临床、病理形态学资料和免疫组织化学，CD30,ALK、CD43、CD45RO、EMA和TIA-1检测结果。结果19例均为原发系统型ALCL，其中男性11例，女性8例，年龄2-71岁，平均26岁。16例（84．2％）出现B症状，14例（73．7％）结外侵犯。肿瘤细胞沿淋巴窦生长或散在分布，均可见标志性肿瘤细胞，CD30^＋19例（100％），ALK（＋）15例（78．9％），EMA（＋）10例（52．6％），TIA-1（＋）14例（73．7％），ALK、EMA和TIA-1同时阴性2例（10．5％）。重新诊断17例（89．5％）正确。结论ALCL表现多样，大部分患者经临床、组织病理学和免疫标记特征综合判断可作出相应诊断，CD30、ALK、EMA、TIA-1对鉴别诊断有帮助。
Objective To investigate the clinicopathology characteristics, immunopheotypic of anaplastic large cell lymphoma （ALCL） in order to improve its diagnostic and therapeutic accuracy. Methods The clinical, immunophenotypic and histopathologic features of 19 cases ALCL were retrospectively studied. The expression of CD30, ALK, CD43, CD45RO EMA and TIA-1 was detected using EnVision immunohistochemical technique. Results All patients were primary systemic ALCL. Among the 19 patients,ll were males and 8 were females. The age ranged from 2 to 71 years, average age 26 years old. It shows a broad morphologie spectrum of the tumor cell and the hallmark cells characterized by sheets of large lymphoid cells with chromatin-poor horseshoe-shaped nuclei containing multiple nucleoli were encountered in all ALCL variants. 16 patients （84.2 % ） showed B-symptoms, and extranodal involvement was present in 14 （73.7 %）. Immunohistochemical study showed that the tumor cells expressed CD30 （100 %）, ALK （78.9 %）, EMA （52.6 %）, TIA-1 （73.7 %） and 2 cases （10.5 %） neither expressed ALK, nor EMA,TIA-1.17 cases were reached the correct diagnosis according to combination of clinic, histological and immunological features. Conclusion The correct diagnosis of ALCL may be reached by combination of clinic, histological and immunological features according to WHO classification. Immunohistochemical staining for CD30, ALK, EMA and TIA-1 is useful in making a correct diagnosis.
出处
《白血病．淋巴瘤》
CAS
2009年第3期158-159,162,共3页
Journal of Leukemia & Lymphoma
关键词
淋巴瘤
大细胞
病理学
Lymphoma, large-cell
Pathology
