摘要
目的检测尖锐湿疣(CA)组织中sFRP-1,wnt-1蛋白表达,了解它们在CA发病中的可能作用。方法采用免疫组化法检测20例CA组织和15例正常包皮组织中sFRP-1,wnt-1蛋白表达。结果CA组织中sFRP-1的表达显著弱于正常包皮组织(P<0.001);wnt-1的表达强于正常包皮组织(P<0.05)。结论CA组织中sFRP-1和wnt-1的表达异常,提示sFRP-1/wnt-1信号通路可能参与CA的发病。
Objective To investigate the expressions of secreted Frizzled Related Protein-1 （sFRP-1） and wnt-1 in patients with condyloma acuminatum（CA）. Methods sFRP-1 and wnt-1 were detected by immunohistoehemistry in 20 CA specimens and 15 normal foreskin tissues. Results The expression of sFRP-1 in CA specimens was significantly weaker than that in normal epithelium tissues（ P 〈 0.001 ）, while wnt-1 was higher than that in normal foreskin tissues （P 〈 0.05 ）. Conclusion The abnormally expressions of sFRP-1 and wnt-1 indicate that they might play an important role in the morbidity of CA.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2009年第3期145-147,共3页
The Chinese Journal of Dermatovenereology
