摘要
目的探讨慢性粒性细胞白血病(CML)的细胞遗传学特点及意义。方法采用24h短期培养法制备骨髓染色体,应用G显带技术进行染色体核型分析。结果194例CML患者中,166例ph+(占85.57%),28例ph-(占14.43%),其中158例具有典型易位,8例复杂变异易位,98例出现其他附加染色体异常,主要为:-22,+8、-21、-11、-10、-14和-20等。结论CML患者进行细胞学研究对疾病的诊断、治疗和判断预后具有重要意义。
Objective ： To explore the characteristic and significance of chromosome changes in patients with chronic myeloid leukemia. Methods ： The chromosomes were obtained by 24h short culturing of bone marrow cell and analyzed under microscope after G - banding. Results： Out of 194 patients with CML, 166 cases （85.57%） were Ph positive and 28 cases （ 14. 43% ） were Ph negative. Among the ph ＋ group, 158 cases （95.18%） carried typical Ph chromosomes and 8 cases （4. 12% ） were complex translocations. Additional chromosome abnormalities were detected in 98 cases （59.04%）, including - 22, ＋ 8, - 21, - 11, - 10, - 14, - 20, et al. Conclusion： The chromosome analysis was helpful in the diagnosis, treatment and prognosis of CML.
出处
《中国优生与遗传杂志》
2009年第3期60-61,共2页
Chinese Journal of Birth Health & Heredity
