摘要
对我院近期耐环丙沙星阴性菌进行了相关因素分析；比较了亚胺培南等１１种抗菌药物对耐药菌的抗菌作用；对临床针对性治疗耐药菌感染提出了建议。结果表明：耐药菌主要为大肠杆菌和克雷伯氏菌。大部分病原菌在接触药物前已对环丙沙星产生耐药性。亚胺培南、第三代头孢菌素和氨曲南对耐药菌的抗菌作用明显较强。提示：遇到病原菌多数为大肠杆菌的泌尿道感染以及病原菌主要为克雷伯氏菌的革兰氏阴性菌肺炎时，不应再以此类药物作为经验性用药方案。严格控制氟喹诺酮类口服制剂在门诊患者中广泛使用是有效减少耐药菌的重要途径。亚胺培南、第三代头孢菌素和氨曲南均可作为针对性治疗耐药菌感染的方案或作为替换用药时的主要品种。
We analyzed correlative factors of the resistance to ciprofloxacin. The activities of 11 antibiotics against ciprofloxacin-resistant bacteria were compared, and some suggestions for treatment were made. Results showed that the resistant bacterial pathogens were mainly Klebsiella and E.coli. Most pathogens had been resistant to ciprofloxacin before being treated by the drugs. The antibacterial activities of imipenem, the third generation cephalosporin and aztreonam were significantly higher than that of ciprofloxacin. This indicated that physicians should not use ciprofloxacin to treat urinary tract infections and pneumonia caused by E.coli and Klebsiella, while sould control the use of fluoroquinolones in outpatients. Imipenem, the third generation cephalosporin and aztreonam can be used as the first choice or replacement drugs for the resistant bacterial infections. This is an important way to reduce the emerging of the resistant bacteria.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1998年第1期45-47,共3页
Chinese Journal of Antibiotics
关键词
环丙沙星
耐药菌
革兰氏阴性杆菌
相关因素
Ciprofloxacin
Resistant bacteria
Gram negative bacteria
Correlative analysis
Specific treatment
