摘要
为研究纳米颗粒进入具有自发曲率的细胞膜的机理,在已建立的受体介导胞吞作用力学模型的基础上进行了扩展,对非零自发曲率的细胞膜上发生的受体介导的胞吞作用进行了研究。结果显示:包裹时间不仅依赖于颗粒的尺寸,而且依赖于细胞膜的自发曲率;存在最佳的颗粒半径使包裹时间最短;对于无限大尺寸的细胞膜,当细胞膜的自发曲率大于临界值时,存在最小和最大包裹半径,但当细胞膜的自发曲率小于等于临界值时,只存在最小包裹半径。
Based on the mechanical model of receptor-mediated endoeytosis, the effect of a spontaneous membrane curvature induced by clathrin or caveolin coats at the inner membrane leaflet was investigated, which is of interest to understanding mechanisms by which nanomaterials might enter into human or animal cells. The results shows that not only the particle size but also the spontaneous membrane curvature can affect the endocytic time; there exists an optimal particles size for the smallest wrapping time; for infinite sized membrane, there exist a minimum and a maximum particle radius, when the spontaneous curvature is above the critical value, and there exists only a minimum particle radius, when the spontaneous curvature is below the critical value.
出处
《清华大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2009年第2期293-296,共4页
Journal of Tsinghua University(Science and Technology)
基金
国家自然科学基金资助项目(10525210
10121202)
