摘要
咪唑与丙烯腈的Michael加成产物与37%甲醛在密闭状态下实现选择性2-羟甲基反应,所得产物与三苄溴季铵化,生成的季铵盐再经Hoffmann型消除反应,高产率地合成了2种含3个2-羟甲基咪唑基衍生物4a,4b,收率>91%.目标化合物的结构经IR,1HNMR,MS谱证实.本文报道的合成方法,操作简便,后处理容易,很好地解决了分离、纯化等问题.
The target compounds 4a, 4b have been efficiently synthesized by tri（bromomethyl）benzene and 1-Cya- noethyl-2-hydroxymethylimidazole obtaining imidazolium salts, following by Hoffmann-type elimination. The 1-Cyanoethyl-2-hydroxymethylimidazole has been selectively gained by 1-cyanoethyl- imidazole which can be gotten by the Michael addition reaction of imidazole and acrylonitrile and 37% formaldehyde in a seal tube at 110℃. The yields of the target compounds are over 91%. And the target compounds have been confirmed by IR, ^1 HNMR and MS. The method reported by this article is easily operated and disposed, what＇ s more, it resolves the problem of separation and purification.
出处
《西华师范大学学报（自然科学版）》
2009年第1期67-70,共4页
Journal of China West Normal University(Natural Sciences)
基金
四川省教育厅自然科学基金重点项目(2004A103)
西华师范大学科研项目启动基金资助项目(05B031)
