摘要
目的研究五味子提取物的最佳包合工艺,增强护肝片中挥发油的稳定性。方法以提取物包合率、包合物收得率为指标,采用L9(34)正交设计法,对五味子提取物进行β-环糊精(β-CD)包合研究。结果最佳包合工艺为提取物与β-环糊精之比1∶9(mL∶g),包合温度30℃,超声时间90min。结论β-环糊精的用量是影响五味子提取物包合效果的主要因素,优选工艺简单、稳定、流程短,可以作为企业的生产工艺。
Objective To research the optimal inclusion process of the extract from SchisandraChinensis(Turcz. ) bait for enhancing the stability of the volatile oil in Hugan Tablets. Methods Taking inclusion rate, inclusion yield as the indexes, L9(3^4) orthogonal design was used for the inclusion research of β-cyclodextrin (β-CD) on the extract in Schisandra Chinensis (Turcz.) bail. Results The best inclusion process was A3B1C3, and the ratio of extract to β-CD was 1:9 (mL :g), the inclusion temperature was 40℃, the ultrasonic time was 90 min. Conclusion The different amount of β- CD is the main factor affecting inclusion. The optimized process is simple, stable with short workflow. It may be used as the production process for enterprise.
出处
《中国药业》
CAS
2009年第6期45-46,共2页
China Pharmaceuticals
基金
黑龙江省教育厅科技攻关项目
项目编号:11531360
关键词
五味子
Β-环糊精
正交设计
Schisandra Chinensis (Turcz.) bail
β - cyclodextrin
orthogonal design