摘要
脑内支架置入后引起血小板-单核细胞聚集体,调整单核细胞的许多行为,诱导单核细胞表达组织因子,促进血管损伤部位血栓内部纤维蛋白的沉积,在支架置入后血管壁损伤的炎症反应中有促进作用。支架置入后P物质明显增多,源于血小板α颗粒的可溶性CD40L,具有促进血小板聚集体的作用,在支架置入后亦明显增多。采用流式细胞术、血小板聚集、血清中可溶性的血小板活化相关分子测定检测中国医科大学附属第一医院神经外科30例患者颅内支架置入前、后血液内血小板的激活和聚集,以探讨脑内支架置入后的凝血反应特点。
Intracranial stent implantation induces platelet-monocyte aggregate, regulates activities of monocyte, induces monocyte expression tissue factors, and promotes fibrin deposition in thrombus at vessel injury site, which promotes inflammatory reaction. P substance significantly increases following stent implantation; platelet a particle-derived soluble CD 40L, which can promote platelet aggregation, also increases after stenting. Flow cytometry, platelet aggregation, soluble platelet activation-related molecule in serum are used to determine platelet activation and aggregation in blood of 30 patients before and after stent implantation from Department of Neurosurgery, First Hospital of China Medical University, so as to explore blood coagulation reaction characters after intracranial stent implantation.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2009年第9期1735-1738,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
