摘要
目的探讨复合聚乳酸羟基乙酸共聚物(PLGA)微球对自制可注射磷酸钙骨水泥(CPC)理化性质的影响及其相互关系。方法将PLGA微球与CPC复合,检测其固化时间、可注射性能、重量丢失、体外降解、抗压强度及微结构改变,并构建重量丢失和抗压强度之间的关系。结果载入药物和微球后,骨水泥的固化时间延长,可注射性能提高,抗压强度下降。电镜示药物复合后CPC大体结构无明显改变,而载入微球后空隙明显增多、增大。CPC/PLGA强度的降低与质量丢失呈负相关。结论CPC与微球复合时会导致其强度的减弱,这一点或许可以通过控制微球的降解来解决。
Objective To investigate correlation between degradation in vitro and compressive strength of a macroporous calcium phosphate cement （CPC）. Methods Poly （lactide-co-glycolide） （PLGA） microspheres were incorporated in to the CPC powder. The setting time, injectability, weight loss with degeneration in vitro, compressive strength and its microarchitecture were detected. Correlation between degradation of extraorgan and compressive strength of the paste was investigated. Results The CPC exhibited a good property of injectability but the self-setting time was slightly prolonged while microspheres were incorporated. With the degradation of PLGA microspheres, the weight loss was increased and the average value of compressive strength of the paste was decreased dramatically. The formulation of negative correlation between compressive and weight loss was established as following：y2 = 0. 794y1＋ 36. 395. Conclusion Regulation the acceleration of degeneration to a proper extents perhaps is another method to enhance the compressive strength in macroporous CPCs.
出处
《山东医药》
CAS
北大核心
2009年第8期9-11,共3页
Shandong Medical Journal
基金
广东省科技计划项目课题(20070328017)
关键词
磷酸钙骨水泥
聚乳酸羟基乙酸共聚物
微球
强度变化
calcium phosphate cement
poly （lactide-co-glycolide）
microspheres
compressive strength
