摘要
目的评价和观察紫杉醇联合顺铂+氟脲嘧啶(5-Fu)化学治疗晚期宫颈癌的疗效及毒副作用。方法将晚期宫颈癌患者分为两组。治疗组161例:化疗第1d:紫杉醇150～180mg/m2静脉滴注3h;第2～6d每天经动脉导管推注5-Fu500mg、顺铂20mg;对照组88例:在第1～7d每天经动脉导管推注5-FU500mg、顺铂20mg。两组均3～4周为1个疗程,连续2～3个疗程。结果化疗结束后4周检查,观察组中39例完全缓解(CR),104例部分缓解(PR),15例病情稳定,3例恶化,治疗有效(CR+PR)率为88.8%;观察组总的5年生存率72.1%。对照组化疗结束后4周检查,88例中,8例完全缓解,66例部分缓解,12例病情稳定,2例恶化,有效率84.1%;对照组总的5年生存率39.8%。两组近期疗效比较,差异无统计学意义(P>0.05);但两组5年后总生存状况比较,差异有显著统计学意义(P<0.01)。结论紫杉醇联合顺铂、5-FU治疗晚期宫颈癌的疗效明显优于顺铂联合5-FU,近期疗效确切,明显提高了患者的5年生存率,达到延长患者生命、提高生存质量的目的。
Objective To investigate the antitumor activity and adverse effect of paclitaxel combined with cisplatin and 5 - fluorouraeil in the treatment of patients with advanced cervical cancer. Methods Patients with advance cervical cancer were divided into treatment group （ n = 161 ） and control group （ n =161 ）. The patients in treatment group were administered paclitaxel 150 - 180 mg/m^2 intravenously 3h on day 1,5 - fluomuracf1500 mg and cisplatin 20 mg intra - arterially via inferior epigastric artery from day 2 to day 7. The patients in control group were administered 5 - FU 500 mg and cisplatin 20 mg intra - arterially via inferior epigastric artery from day 1 to day 7. The treatment lasted for 2 - 3 treatment courses with 3 -4 wks treatment as one course. Results The investigation 4 wks after the chemotherapy found that of the 161 patients in treatment group, 39 achieved complete remission, 104 achieved partial remission, 15 remained stable and 3 showed disease progression. The response rate and 5 -year survival rate of the patients in treatment group were 88.8% and 72.1% respectively. In control group, 8 achieved complete remission, 66 achieved partial remission, 12 remained stable and 2 showed disease progression; the response rate was 84.1% and 5 -year survival rate was 39.8%. Although the shortterm effect was not significantly different between the two groups （ P 〉0.05）, 5 -year survival rate in the treatment group was significantly improved compared with that of the control group （ P 〈0.01 ）. Neither chemotherapy related death nor obvious toxicities were observed during the study. Conclusion The combined chemotherapy of paclitaxel, cisplatin and 5 - fluoreuraeil shows clinical efficacy and improved 5 - year survival compared with those of cisplatin and 5 - fluorouraeil combination in the treatment of patients with advanced cervical cancer.
出处
《临床和实验医学杂志》
2009年第3期33-35,共3页
Journal of Clinical and Experimental Medicine
关键词
宫颈癌
紫杉醇
顺铂
氟脲嘧啶
化疗
Cervix neoplasms
Paclitaxel
Cisplatin
Fluorouracil
Chemotherapy
