摘要
目的：了解慢性肾功能不全患者不同病期血浆白细胞介素８（ＩＬ８）的含量及其临床意义。方法：用双抗夹心酶联免疫吸附法分别测定慢性肾功能不全患者不同病期血浆ＩＬ８含量，并与正常对照组比较。结果：慢性肾功能不全代偿期及氮质血症期患者血浆ＩＬ８略低于正常对照组，但差异无显著性（Ｐ均＞０．０５）。肾功能衰竭期患者血浆ＩＬ８含量显著低于正常对照组（Ｐ＜０．０１）。在慢性肾功能不全病程中，血浆ＩＬ８含量与血肌酐、尿素氮呈显著负相关（ｒ＝－０．５８，Ｐ＜０．０１；ｒ＝－０．５１，Ｐ＜０．０１）。结论：慢性肾功能不全患者肾功能衰竭期机体全身免疫功能低下，急性炎症反应减弱。
Objective:To investigate the significance of changes in plasma interleukin8(IL8) levels in patients with chronic renal insufficiency (CRI) at different stages.Methods:Plasma IL8 levels were measured in CRI patients and normal subjects by sandwich enzyme linked immunosorbent assay.Results:Plasma IL8 levels in CRI patients during compensative stage and decompensative stage were slightly lower than that in normal controls (both P >0 05),but in patients with chronic renal failure stage it was significantly decreased compared to normal controls ( P <0 01).During the development of CRI,IL8 levels were negatively correlated with creatinine and blood urea nitrogen ( r = -0 58 , P <0 01,and r =-0 51, P <0 01,respectively).Conclusions:Low plasma IL8 levels may be involved in the pathogenesis of the host cellular immune dysfunction in chronic renal failure.
出处
《中国危重病急救医学》
CSCD
1998年第5期296-297,共2页
Chinese Critical Care Medicine
基金
湖南省中医药管理局青年科研基金
