摘要
目的:分析抗肿瘤药致药品不良反应(ADR)的特点与规律。方法:对2003～2007年国家知识基础设施(CNKI)收录的抗肿瘤药致ADR病例报告112例,分别从患者性别、年龄、原发疾病、药品种类、涉及器官或系统及临床表现等方面进行统计、分析。结果:112例ADR报告中,51～60a的患者ADR发生率最高(占31.3%),以铂类抗肿瘤药发生率最高(占36.6%),ADR最为常见的临床表现为神经系统损害(占41.1%),其次为呼吸系统(占32.1%)以及皮肤及其附件(占28.6%)损害。结论:应加强医务人员对抗肿瘤药致ADR的上报意识,分析ADR的发生特点,确保临床安全、合理使用抗肿瘤药,减少或避免ADR的发生。
OBJECTIVE： To analyze the characteristics and genernal patterns of adverse drug reactions （ADR） induced by antitumor drugs. METHODS： 112 ADR cases induced by antitumor drugs included in CNKI from 2003 to 2007 were analyzed statistically in respect of patients＇ age and sex, primary diseases, drug categories, organs and systems involved and the clinical manifestations etc. RESULTS： Of the total 112 cases, patients aged from 51 to 60 years showed the highest incidence of ADR, accouting for 31.3%, and Platinum antitumor drugs showed the highest incidence of ADR, accounting for 36.6%. The most common presentation of ADR was lesion of nervers system（41.1% ）, followed by lesions of respirotory system （32.1% ） and skin and the appendants （28.6%）. CONCLUSION： Awareness on the reporting of ADR induced by antitumor drugs should be strengthened and the characteristics of the ADR should be analyzed to ensure clinical safe and rational use of antitumor drugs and avoid or reduce the incidence of ADR.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第8期617-618,共2页
China Pharmacy
关键词
抗肿瘤药
药品不良反应
文献分析
Antitumor drugs
Adverse drug reaction
Literature analysis
