摘要
（目的）探讨EB病毒在鼻咽癌发病中的作用。（方法）应用免疫组化技术分别检测46例鼻咽癌中EB病毒潜在膜蛋白（LMP－1）、p53及bcl－2蛋白表达。（结果）LMP－1的阳性率为52．2％（24/46）；24例LMP－1阳性病例中p53阳性16例、bcl－2阳性20例，22例LMP－1阴性病例中P53和bcl－2阳性分别有15例和18例，两组间无明显差异（P＞0．05）。〔结论〕LMP一1对p53和bcl-2表达无明显影响。
PurposeTo study the role of EB virus infection in nasopharyngeal carcinoma(NPC). Method With immunohistochemistry technique, expression of latent membrane proteni (LMP-1) and P53 and bcl-2 positive were found in 16 cases and 20 cases respectively. OfLMP-1 was 52.2%(24/26). Of 24 cases of LMP-1 positive,P53 positive and bcl-2 positive were found in 16 cases and 20 cases respectively. Of22 cases of LMP-1 negative,pisitive P53 and bcl-2 were fond in 15 and 18 cases respectively. No sighficant different was found (P>0.05).Conclusion LMP-1 may have no clear effect on expression of p53 and bcl-2.
