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产ESBLs肺炎克雷伯菌Ⅰ类整合子基因盒的研究 被引量:6

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摘要 目的探讨整合子参与产ESBLs肺炎克雷伯菌多重耐药的分子机制。方法整合酶基因扩增法检测I类整合子;整合子可变区扩增并测序。结果8株产ESBLs肺炎克雷伯菌中有7株Ⅰ类整合子检测阳性,其中4株耐药基因盒为dfrA12-orfF-aadA2,2株为dfrA17-aadA4/aadA5,1株为aadA2,1株未检测到耐药基因盒。结论整合子介导的耐药基因盒参与了产ESBLs肺炎克雷伯菌多重耐药的形成,应引起高度重视。
出处 《中国微生态学杂志》 CAS CSCD 2009年第2期169-170,共2页 Chinese Journal of Microecology
基金 2008年汕头市重点科技计划项目(汕府科[2008]85号)
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