摘要
目的 探讨肾血管病变与肾小球病理改变之间的关系。方法 回顾性分析肾活检病例1833例，其中IgA肾病1093例，非IgA肾病740例。采用方差检验对各组资料进行统计分析。结果在1093例IgA肾病中有肾血管病变者426例，占39％，在740例非IgA肾病中存在肾血管病变者为182例占25％，两者有显著性差异（P〈0．01）。在IgA肾病的肾血管病变中，主要是以肾小动脉内膜增厚、纤维化及管腔狭窄病变为主。IgA肾病各亚型中存在肾血管病变的分布为：轻微病变型22．5％（36／160），局灶节段增生型41％（195／476），系膜增生型39．1％（135／345），硬化型93．1（27／29）。此分布的不同具有显著性差异（P〈0．01）。结论IgA肾病通常会伴有多种肾间质血管病变，并且血管病变与IgA肾病的病理改变及临床特点密切相关，提示肾血管病变是影响IgA肾病发展的重要因素。
Objective To investigate the relationship between the renal vascular lesions and glomerular pathological changes. Methods To analyze 1833 renal biopsy cases with 1093 cases of IgA nephropathy and 740 eases of non - IgA nephropathy, retrospectively. Vascular disease was divided into renal artery lesions, renal arteriolar lesions, renal small arteries and arterioles United lesions. Results It was showed that 426 （39.0%） cases exhibited vascular lesions in 1093 patients with IgAN and 182 （24.6%） cases in 740 patients with non -IgAN nephropathy, respectively. There were significant difference on different distributing of vascular lesions between IgAN and non IgAN （P 〈 0.01 ）. The incidence of vascular lesions were different In different subtype of IgAN with 22.5% in minimal lesion, 41.0% in focal segmental proliferation, 39. 1% in mesangial proliferation mad 93.1% in glomerulosclerosis. The vascular lesions aggravation was paralleled to increased pathological changes of IgAN. Moreover, the results also showed the close correlation between the degree of interstitial inflam- mation and vascular lesions aggravated in IgAN. Conclusion The vascular lesions in IgAN may be an important factor to affect pathological changes and prognosis of IgAN.
出处
《中国医学创新》
CAS
2009年第8期9-11,共3页
Medical Innovation of China
