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血压昼夜节律改变和颈动脉内膜-中层厚度的关系 被引量:3

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摘要 目的探讨高血压昼夜节律改变和动脉粥样硬化严重程度的关系,以及施慧达的干预作用。方法观察门诊和住院的勺型高血压患者145例,非勺型高血压患者77例,均为停用其他降压药并经5个半衰期药物洗脱后开始服用施慧达10mg/d~20mg/d,维持血压尽量达标。在治疗开始、治疗6个月、治疗12个月时由同1位B超医师,同1台彩超进行颈动脉内膜中层厚度(IMT)测量及斑块检出进行对比分析。结果非勺型高血压组与勺型高血压组治疗前IMT比较斑块栓出率为75.3%、51.0%(P<0.05)。而治疗后组内比较,治疗6个月时IMT有所减退,但无统计学意义,12个月时两组IMT与治疗前比较具有统计学意义(P<0.05)。随着时间的延长IMT减退和斑块检出率降低越来越明显。结论非勺型高血压患者更容易发生IMT增厚及粥样斑块的形成,施慧达有逆转IMT增厚和消除粥样斑块的作用。
出处 《中西医结合心脑血管病杂志》 2009年第3期351-352,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
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