摘要
目的研究不同剂量阿托伐他汀对不稳定型心绞痛患者高敏C反应蛋白的影响。方法将85例UAP患者随机分为两组,一组给予小剂量阿托伐他汀10mg/d,而另一组给予大剂量阿托伐他汀40mg/d,2周后比较治疗前后hs-CRP及血脂的变化情况。结果两组hs-CRP均显著下降,大剂量强化降脂组比常规降脂组下降更明显,有统计学差异P<0.01。结论阿托伐他汀能降低UAP患者hs-CRP,大剂量的作用更为显著,未出现副作用。
Objective To study the effect of varying dosage of atorvastatin on hs-CRP level in UAP patients. Methods Eighty-five UAP patients were randomly divided into two groups,the one received a small-dosage atorvasatin 10mg per day,and the other was given a large-dosage atorvastatin 40mg per day. After two weeks,the hs-CRP level before and after treatment was compared between two groups. Results Both two groups showed a marked decrease in hs-CRP level,and the large-dosage group was reduced significantly in comparison with the small-dosage group, with a statistical difference between them, P〈 0.01. No considerable adverse-reaction was appeared. Conclusion Atorvastatin can considerably reduce the hs-CRP level in patients with UAP, especially when administered in a large-dosage（40mg/d）.
出处
《中国现代医生》
2009年第8期36-37,共2页
China Modern Doctor
