摘要
目的探讨不同剂量托吡酯对伴中央颞区棘波的良性局灶性癫癎(benign epilepsy of childhood with centrotemporal spikes,BECTS)患儿事件相关电位P300的影响。方法对30例BECTS患儿在服用托吡酯不同剂量的阶段分为A,B两组,A组是在托吡酯加量至每日2mg/kg后服药6个月测其P300的潜伏期和波幅,然后此30例病人继续增加托吡酯的量至每日5mg/kg后服药6个月后作为B组再测其P300的潜伏期,波幅,比较不同剂量对P300的变化来反映其对认知功能的影响。结果A组服药前后P300电位潜伏期波幅比较,差异无显著性(P>0.05),B组服药前后P300电位潜伏期波幅比较,差异有显著性(P<0.01)。结论托吡酯对癫癎患儿认知功能的影响与用药剂量大小相关联。
Objective The event related potential （ERP-P300） is useful to determine cognitive disturbances. This study examined the changes of ERP-P300 following different dosages of topiramate （TPM） treatment in children with epilepsy in order to investigate the effect of different dosages of TPM on cognitive function. Methods Thirty cases of benign childhood epilepsy with centrotemporal spikes （BECTS） were first administered with TPM at a dosage of 2 mg/kg · d for 6 months. Afterwards they received another 6 months of TPM treatment at a dosage of 5 mg/kg · d. ERP-P300 was tested before and after different dosages of TPM treatment. Results There were no significant differences in the latency and amplitude of ERP-P300 before and after 6 months low dosages of TPM treatment. However, the latency was more prolonged and the amplitude was reduced in the ERP-P300 testing after 6 months high dosage of TMP treatment （ P 〈 0.01 ）. Conclusions The effect of TPM on cognitive function is related to its dosage in children with epilepsy.
出处
《中国当代儿科杂志》
CAS
CSCD
2008年第5期583-585,共3页
Chinese Journal of Contemporary Pediatrics
