摘要
目的:观察急性心肌梗死早期内源性松弛素(H2RLX)和Ⅰ型前胶原C端末端肽(PICP)、转化生长因子(TGF-β1)的的表达。方法:入选41名急性心肌梗死患者和冠脉血管正常的对照组10名。心肌梗死后3d、7d分别抽静脉血,用ELISA方法检测H2RLX和PICP、TGF-β1,对照组在入选后抽静脉血检测H2RLX和PICP、TGF-β1。结果:(1)心肌梗死后3dH2RLX与对照组比较,没有显著差异。梗死后3d和7d的H2RLX水平没有明显变化。(2)梗死后3dPICP水平显著高于对照组,PICP在梗死后7d的水平显著低于梗死后3d的水平。(3)梗死后3dTGF-β1与梗死后7dTGF-β1保持在较高水平,两个时点的TGF-β1水平均明显高于对照组。(4)梗死后7d松弛素水平和心肌梗死组的空腹血糖呈正相关。结论:在心肌梗死早期血浆中没有内源性松弛素表达的增加,但心肌胶原形成及前纤维化因子表达增加。
AIM： To investigate the changes in parameters related to myocardial fibrosis of H2 relaxin （H2RLX） and procollagen type IC -terminal peptide （PICP）, transforming growth factor - β1 （TGF -β1 ） level in the plasma after acute anterior myocardial infarction. METHODS： Forty - one patients with anterior myocardial infarction （MI） and 10 controls with normal coronary vessels were selected. Plasma H2RLX, PICP, and TGF - β1 levels were determined by enzyme linked immunosorbent assay （ELISA） in 10 control subjects and 41 post - MI patients at day 3 and 7 post - MI. RESULTS ： （ 1 ） H2RLX level at day 3 post - infarct had no difference between the patients and the controls. No marked change in H2RLX at day 3 versus day 7 post - infarct Was observed. （2）The level of PICP at day 3 post - infarct was markedly increased followed by a fall at day 7 post -infarct, but was still higher than that in control. （3） TGF - β1 level, which was similar at day 3 and 7 post - infarct, was higher than that in control. （4） At day 7 post - infarct, the level of H2RLX was positively correlated with the fasting blood glucose in MI group. CONCLUSION： In early period of acute MI, profibrotic factors such as TGF - β1 expression and collagen expression increase. However, antifibrotic relaxin has no change.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2009年第3期472-475,共4页
Chinese Journal of Pathophysiology
关键词
心肌梗死
心肌纤维化
松弛素
转化生长因子Β
Myocardial infarction
Myocardial fibrosis
Relaxin
Transforming growth factor beta
