摘要
目的了解2005～2008年河北省儿童流感病毒感染的流行情况。方法狗肾传代细胞(MDCK)进行流感病毒分离,用血凝试验、血凝抑制试验进行型和亚型的鉴定。结果2005年10月至2008年3月共采集流感样患儿咽试子标本2 071份,分离出205株流感病毒,检出率为9.90%。2005～2006年流行期流感病毒分离阳性率为10.05%,H1N1优势株;2006～2007年流行期分离阳性率为11.85%,以H3N2占优势;2007～2008年流行期分离阳性率为8.08%,B型流感病毒替代了A型流感病毒占据优势地位,B型yamagata系成了优势株。按月统计流感病毒分离阳性率高峰在每个流行期的1月或3月;3岁以上儿童流感病毒分离阳性率高于3岁以下儿童。结论近年来河北省儿童中同时流行着H1N1、H3N2亚型和B型流感病毒,然而,不同年份优势株不一样。儿童流感病毒阳性率3岁以上是高峰年龄段,冬春季是发病高峰季节。
Objective To analyze the activity of influenza viruses in children from 2005 to 2008 in Hebei. Methods The influenza virus was isolated by MDCK cell culture. The isolates was identificated with hemagglutination test（HA） and hemagglutination inhibition tests（HI）. Results 2 071 throat swab specimens from children with influenza like illness were collected in Hebei from Oct. 2005 to Mar. 2008 and 205 strains（9.90% ） of influenza viruse were isolated. The influenza viruses isolation rate was 10.05% from 2005 to 2006 and the predominant strain of influenza viruses was H1N1 subtype. The positive rate of influenza viruses wasl 1.85%, H3N2 subtype was the predominant strain from 2006 to 2007. But the predominant position of influenza A virus was substituted by influenza B virus, and B Yamagata lineage was prevailing one. The peak of influenza viruses isolation rate was in March or January. The isolated positive rate of influenza viruses in children above 3 years of age was higher than that in children below 3 years of age. Conclusion Influenza A subtype H1N1 and H3N2 as well as B type viruses were co-circulating in children in Hebei in recent years, the predominant strain of influenza virus was different years. The positive rate of influenza viruses in children above 3 years of age was the age range of attack peak. The most prevalent season was in spring and winter.
出处
《河北医药》
CAS
2009年第3期281-282,共2页
Hebei Medical Journal
基金
河北省科学技术厅科学技术研究与发展计划项目(编号:07276917)
关键词
流感病毒
儿童
河北省
influenza virus
children
Hebei province
