摘要
目的了解葡萄球菌属对抗菌药物的耐药性,为临床治疗提供依据。方法对临床分离的葡萄球菌属使用全自动微生物分析仪(VITEK-32)鉴定到种,药敏试验及D-试验采用纸片扩散法(K-B法)。结果206株金黄色葡萄球菌中耐甲氧西林金黄色葡萄球菌(MRSA)的检出率为64.1%,MRSA对27种抗菌药物中19种耐药率>50.0%,对12种青霉素类、头孢菌素类以及亚胺培南100.0%耐药,MRSA和MSSA对利奈唑胺、万古霉素100.0%敏感,未检测到耐万古霉素金黄色葡萄球菌;D-试验检出率为78.7%。结论MSSA对大部分抗菌药物仍保持较好的敏感性,而MRSA表现为多药耐药性;检测克林霉素诱导型耐药具有重要的临床应用价值。
OBJECTIVE To investigate the antibiotic resistance of Staphylococcus aureus isolates from the clinical samples from 2005 to 2007. METHODS The susceptibility tests and D-test were performed by the disk diffusion method and their results were analyzed by the software WHONET 5. 4. RESULTS The rate of MRSA isolates accounted for 64. 1%. The resistance rate to 12 kinds of the antimicrobial agents, such as penicillins, cephalosporins and carbapenems was 100%. The MRSA and MSSA were susceptible to linezolid and vancomycin. No isolates were resistant to vancomycin in our hospital; the positive rate of D-test was 78.7%. CONCLUSIONS MSSA is still sensible to most of the antimicrobial agents, but MRSA shows multidrug resistance. The D-test is of great clinical importance.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第6期680-682,共3页
Chinese Journal of Nosocomiology
基金
宁夏自然科学基金资助项目(NZ0667)
关键词
金黄色葡萄球菌
耐药性
抗菌药物
Staphylococcus aureus
Resistance
Antimicrobial agents
