摘要
目的探讨老年急性脑梗死(ACI)患者血浆同型半胱氨酸(Hcy)水平与颈动脉粥样硬化(CAS)斑块及其硬化程度的关系。方法93例确诊的ACI患者均接受颈动脉彩色多普勒超声仪检查,测量左右颈总动脉内-中膜厚度(IMT),根据测量结果分为有CAS斑块组(60例)和无CAS斑块组(33例);将患者CAS程度分为0～4级。采用循环酶法检测两组ACI患者血浆Hcy水平,对血浆Hcy水平与CAS的斑块及其硬化程度分级进行相关性分析。结果老年ACI患者有CAS斑块组血浆Hcy浓度[18.83(15.20～24.03)μmol/L]明显高于无CAS斑块组[12.30(9.70～15.10)μmol/L](P<0.05);且有CAS斑块组高Hcy血症发生率(36.67%)较无CAS斑块组(12.12%)显著增高(P<0.05)。CAS程度:0级组、1级组分别与3级组,0级组、1级组、2级组分别与4级组的血浆Hcy水平比较差异有统计学意义(均P<0.005)。结论老年ACI患者中,CAS斑块形成可能与血浆Hcy水平升高有关;CAS程度愈高,其相关性愈大。
Objective To investigate the correlation between the plasma homocysteine （Hcy） level and the plaque and its degree of the carotid atherosclerosis （CAS） in elderly patients with acute cerebral infarction （ACI）. Methods 93 definit ACI patients recieved the colour Doppler ultrasonograph to detect the intima-media thickness （IMT） of bilateral carotid arteries. Then, the patients were divided into group with CAS plaque（60 cases） and group without CAS plaque （33 cases） according to the result of the detection. Also the degree of CAS were divided to 0 -4 levels. The concentration of plasma Hcy of all the patients were measured by enzymatic cycling assay. The correlation analysis was made between plasma Hey levels and the CAS plaque and the degree of CAS. Results The concentration of plasma Hey in the group with CAS plaque [ 18.83 （15.20 -24.03 ）μmol/L ] was significantly higher than that in group without CAS plaque [ 12.30 （9.70-15. 10）μmol/L] （P〈 0.05）. The incidence of hyperhomoeysteinemia in the group with CAS plaque was also significantly higher than that in group without CAS plaque（P〈0.05）. The concentration of plasma Hcy in 3 degree of CAS compared with 0 -1 degree, in 4 degree of CAS compared with 0 - 2 degree were reached the statistic significance （ all P 〈 0. 005 ）. Conclusions The formation of CAS plaque may be closely associated with the increased level of plasma Hcy in the elderly patients with ACI. The higher CAS degree is the more correlation exist.
出处
《临床神经病学杂志》
CAS
北大核心
2009年第1期30-32,共3页
Journal of Clinical Neurology
