摘要
1-溴-2-甲氧基萘与0-对甲基苯磺酰乳酸乙酯(1)在无水氯化铝催化下经Fniedel-Crafts反应,还原脱溴直接合成dl-萘普生(3),以上反应均在“一锅”内完成,收率达95％(以1-溴-2-甲氧基萘计算)。
dl-Naproxen was directly synthesized via reduction and hydrolysis of ethyl (5-bromo-6-methoxy-2-naphthyl )-a -methyl acetate (2), which was prepared by Friedel-Crafts reaction with 1-bromo-2methoxynaphthalene and ethyl 0-(p-methyl benzene sulfonyl) lactate under the catalysis of anhydrous AlCl3, all reactions were carried out in one-pot to afford dl-naproxen in about 95% yield from 1-bromo-2-metboxynaphthalene.
出处
《中国现代应用药学》
CAS
CSCD
1998年第2期32-33,共2页
Chinese Journal of Modern Applied Pharmacy
基金
湖北工学院青年基金项目
关键词
萘普生
还原脱溴
工艺
羧烷基化
dl-naproxen, friedel-crafts reaction, reduction-debromination
