摘要
目的探讨以乳胶增强免疫比浊法测定的血清胃蛋白酶原(PG)Ⅰ、PGⅡ、PGⅠ/PGⅡ(PGR)水平在胃癌筛查中的价值。方法根据组织病理学检查结果将受检者分为4组,正常对照组60例、萎缩性胃炎组160例、消化性溃疡组65例、胃癌组55例。以乳胶增强免疫比浊法检测受检者空腹血清PGⅠ、PGⅡ的水平。结果萎缩性胃炎组和胃癌组的PGⅠ和PGR水平显著降低(P<0.05)。消化性溃疡组PGⅠ,PGⅡ明显升高(P<0.05)。根据流行病学原理,确定以PGⅠ≤70ng/mL和PGR≤4为界值(敏感性为69.09%,特异性70.65%)筛查胃癌。结论乳胶增强免疫比浊法测定的血清PG水平在胃癌筛查中有重要的应用价值。
ObjectiveTo evaluate the use of latex-enhanced immunoturbidimetry of serum tests： serum PG Ⅰ, PG Ⅱ, PG Ⅰ/PG Ⅱ ratio （PGR） to screen of gastric cancer.MethodsThese patients were divided into 4 groups based on endoscopic and histopathological findings： 160 patients in atrophic gastritis group, 55 in gastric cancer group, 65 in digestive ulcer group and 68 served as control group. Fasting serum samples for PG Ⅰ and PG Ⅱ, de-termination were analyzed by latex-enhanced immunoturbidimetry.ResultsPG Ⅰ and PGR values decreased sig-nificantly in both atrophic gastritis and gastric cancer groups （P 〈0.05）. PG Ⅰ and PG Ⅱ values increased signifi-cantly in digestive ulcer group （P 〈0.05）. Based on epidemiology, for the best discrimination of gastric cancer, the cut-off values of PG Ⅰ and PGR were 70 ng/mL and 4 （sensitivity 69.09%, specificity 70.65%）.ConlusionThe use of latex-enhanced immunoturbidimetry of serum tests： serum PG Ⅰ, PGⅡ, PG Ⅰ/PG Ⅱ ratio （PGR） to screen of Gastric Cancer have impotant application value.
出处
《中国内镜杂志》
CSCD
北大核心
2009年第2期135-139,共5页
China Journal of Endoscopy
基金
吉林省科技发展计划项目资助<人胃癌癌变相关蛋白分子的筛选及功能分析>
项目编号:20070729-8
