摘要
目的：探讨阿立哌唑合并舍曲林治疗难治性抑郁症的效果。方法：将68例难治性抑郁症患者随机分成2组，分别给予阿立哌唑合并舍曲林（合用组）与单用舍曲林（单用组）治疗12周，以汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）评定临床疗效，以不良反应症状量表（TESS）和相关检查评定不良反应。结果：治疗结束时两组HAMD和HAMA的评分均显著降低，以合用组疗效显著而快。结论：阿立哌唑合并舍曲林治疗难治性抑郁症的疗效优于单用舍曲林，且耐受性好。
Objective ： To explore the effect of Aripiprazole combined with Sertraline in the treatment of treatment resistant depression. Methods ：68 patients with treatment resistant depression were randomly assigned into two groups, Aripiprazole combined with Sertraline and Sertraline alone for 12 weeks. The clinical efficacy were evaluated by the Hamilton depressive scale （HAMD） and the Hamilton anxiety scale （HAMA）, Adverse events were assessed by the treatment emergent symptom scale （TESS） and related laboratory examinations. Results： As compared with the baseline scores, the HAMD scores, as well as HAMA scores, decreased significantly after 12 weeks＇ treatment （P 〉 0.05 ）, especially for the patients treated by combination of Aripiprazole with Sertraline. Conclusions： The combination of Aripiprazole with Sertraline is better than Aripiprazole alone in the treatment of treatment resistant depression.
出处
《中国民康医学》
2009年第5期448-449,452,共3页
Medical Journal of Chinese People’s Health
关键词
阿立哌唑
舍曲林
难治性抑郁症
疗效
Aripiprazole
Sertraline
Treatment resistant depression
Efficacy
