摘要
三氟甲基氯苯与氰化钾在经还原性金属粉末还原生成的三(三苯基膦)合镍(0)催化下反应得到三氟甲基苯甲腈,再与H2S发生加成反应,生成对三氟甲基苯硫酰胺。试验了各种条件对反应的影响,产品收率达90%,纯度达97%,并经IR和GC-MS检测,结构正确。工艺操作简单、反应条件温和。
p-trifluoromethylbenzonitrile was prepared from p-(trifluoromethyl)chlorobenzene and potussium cyanide catalyzed by tris(triphenylphosphine)nickle(0), which was prepared from anhydrous NiCl2 and triphenylphosphine in the presence of zinc.And then, the produced intermideate, p-trifluoromethylbenzonitrile was treated with hydrogen sulfide to give p-(trifluoromethyl)thiobenzamide and the yield of 90% with the purity of 99.7% was obtained for the objective product.The structure is correct through IR and GC-MS testing.The operation process is simple and reaction condition is moderate.
出处
《化工生产与技术》
CAS
2009年第1期1-4,共4页
Chemical Production and Technology
基金
国家科技支撑计划课题(2007BAI34B07)
国家自然科学基金项目(20776127)
浙江省科技计划项目(2008C01006-1)
