摘要
目的:观察健儿强身膏对支气管哮喘豚鼠模型的治疗作用。方法:采用卵蛋白(OVA)致敏法制备豚鼠哮喘模型,将豚鼠随机分为6组,即空白对照组、模型组、阳性对照组、健儿强身膏(高、中、低)3个剂量组,分别观察引喘潜伏期(T)、支气管肺泡灌洗液(BALF)中嗜酸细胞(EOS)数目和脾肺脏器系数。结果:健儿强身膏3个剂量组均能延长豚鼠哮喘诱发潜伏期,与模型组比较差异显著(P<0.05);模型组BALF细胞计数及EOS量显著增高,健儿强身膏各剂量组BALF中EOS数均少于哮喘组(P<0.05);模型组脾脏系数低于正常,健儿强身膏可恢复脾脏系数(高剂量组P<0.05)。结论:健儿强身膏对支气管哮喘具有较好的治疗效果,其作用与促进机体的免疫力有关。
Objective： To observe the effect of Jianerqiangshen electuary on experimental asthma in guinea pigs. Methods： The asthma guinea pig model was established by the ovalbumin（OVA） challenge methods. Forty-eight guinea pigs were randomly divided to six groups： the normal control group, the asthma model group, the DXM treated group, and three dose groups of Jianerqiangshen electuary. The effects of relieving asthmatic attack were observed. The changes of eosinophils （EOS） in bronchi-alveolar leveler fluid （BALF） and the organ indexes of the spleen were tested. Results： Compared with the model group, Jianerqiangshen electuary groups could prolong the asthmatic model＇ s the latent period of asthmatic attack （P〈0.05）.The number of EOS cells in BALF decreased by using Jianerqiangshen electuary treatment group （P〈0.05）. The indexes of spleen differences were significant between the high dose of Jianerqiangshen electuary group and the model group（P〈0.05）. Conclusion： Jianerqiangshen eleetuary has good efficiency to asthma in guinea pigs.
出处
《交通医学》
2009年第1期9-11,14,共4页
Medical Journal of Communications
基金
南通市社会发展计划项目(S5816)
关键词
健儿强身膏
豚鼠
哮喘
嗜酸性粒细胞
脏器系数
Jianerqiangshen electuary
guinea pigs
asthma
eosinophils
organ index
