摘要
[目的]探讨低体重婴幼儿体外循环（CPB）手术围术期联合应用乌司他丁与氨溴索的肺保护效果。[方法]以60例体重7奴及以下的先天性心脏病室间隔缺损患儿为研究对象，随机分四组（每组15例）：氨溴索组（A组，氨溴索20mg／kg·d）、乌司他丁组（U组，乌司他丁1～2万U／d），联合组（AU组）按A、U组方案联合应用氨溴索和乌司他丁，对照组（C组）为空白对照，仅予以常规处理。以动态肺顺应性（Cd）、静态肺顺应性（Cs）以及呼吸指数（RI）来评价术后早期肺功能改变。[结果]手术后1h，AU组Cd优于A组、C组，RI优于A组、U组；手术后24h，AU组Cd和RI优于其他组，Cs优于A组、U组。[结论]围术期联合应用乌司他丁和氨溴索可抑制婴幼儿CPB术后炎症反应，改善术后肺功能，其效能大于其中任一药物单用。
[Objective] To study the lung protective effects of combined perioperative administration of ulinastatin and ambroxol in infants who underwent cardiac operation under cardiopulmonary bypass （CPB）. [Methods] Sixty infants （weight less than 7 kilograms） with ventricular septal defect were divided randomly into four groups. The control group （Group C） was treated commonly, and the Group A was injected with ambroxol perioperatively, and the Group U was treated with ulinastatin and the Group AU was administrated with ulinastatin and ambroxol. The thoracic lung compliance （Cs）, dynamic lung compliance （Cd） and respira- tory index （RI） were measured at the beginning of CPB （T1）, 1 hour （T2） and 24 hour （T3） after the CPB. [Results] At T2, Group AU had a higher Cd value than that of Group A and C, and a lower RI value than that of Group A and U. At T3, the Group AU had a higher Cd value and a lower RI value than those of other groups, and a higher Cs value than that of Group A and U. [Conclusion]The perioperatively combined administration of ulinastatin and ambroxol has synergistic effect on lung protection, and can palliate the lung injury caused by CPB and improve the lung function.
出处
《医学临床研究》
CAS
2009年第2期193-196,共4页
Journal of Clinical Research
基金
湖南省自然科学基金课题（06TJ41078）
