摘要
绿茶的主要成分之一茶多酚由多种儿茶素组成,其中没食子儿茶素没食子酸酯(EGCG)含量最多.大量研究表明,绿茶的抗肿瘤作用主要与该分子有关.EGCG具有强烈的抗肿瘤作用,其机制复杂,如抑制细胞分裂、诱导细胞凋亡、抑制血管生成等等.最近又发现了很多新的机制,如EGCG对67kDa层黏连蛋白受体及AKT信号传导系统的作用等.EGCG抗肿瘤作用机制正逐渐变得清晰起来.本文综合了最新的发现和已证实的研究结论,对EGCG抗肿瘤机制作一综述,期待可以为新一代化疗药物的进一步深入研究提供依据.
Green tea is a worldwide popular beverage, which is found to have a broad anticancer activity. Polyphenol, one of the major constituents of green tea, is composed of catechins, mainly （-）-epigallocatechin-3-gallate （EGCG）. It is known anticancer effects of green tea are associated with this component. It has been well established that EGCG has strong anticancer effects. Studies have shown that the mechanisms through which EGCG exerts its anticarcinogenesis potential are very complex, such as cell division, apoptosis induction, angiogenesis inhibition, and so on. Recently, many new findings have been reported, like the action on 67 kDa Laminin receptors and AKT signaling pathway, which are not well covered by the previous researches. The mechanisms of its anticancer effects are becoming clear. In this paper we mainly discussed the mechanisms of anticancer effects of EGCG, based on the latest findings and proved conclusions, in hope of providing rationale for future cancer managements and giving enlightenment to the design of nextgeneration chemotherapeutics.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第3期229-235,共7页
World Chinese Journal of Digestology
