摘要
目的观察妊娠高血压大鼠(PIH)与正常妊娠大鼠下丘脑室旁核(PVN)、视上核(SON)及孤束核(NTS)内血管紧张素Ⅱ1型受体(AT1)免疫阳性神经元的分布。方法用免疫荧光染色技术对PIH大鼠AT1分布的神经元进行了研究,并与正常大鼠进行比较。结果两组大鼠PVN、SON、NTS内AT1免疫阳性神经元的分布与形态基本类似。数据经统计学处理,结果表明,PIH组大鼠PVN和NTS内AT1阳性细胞数目较对照组多,而两组大鼠SON内AT1的表达无明显差异。结论实验结果提示AT1在下丘脑PVN和NTS内的血压神经内分泌调节活动中起着重要的介导作用,中枢AT1受体的异常增加可能与母体妊高征的发病有关。
Objective The distribution of angiotensin Ⅱ type 1 receptor （AT1） immunoreactive neurons was investigated in paraventricular nucleus （PVN）, supraoptic nucleus （SON） and nucleus of solitary tract （NTS） of the pregnancy-induced hypertension symptom rats （PIH） and normal rats. Methods The morphology and distribution of ATl immunoreactive neurons were observed respectively in PVN, SON and NTS of both PIH rats and control rats by using immuno-fluorescence methods in the same sections. Results The morphology and distribution of AT1 immunoreactive neurons were fundamental similarity in the three nucleus. The results showed that the number of AT1 positive neurons in PVN and NTS of PIH was much more than that of control group （P〈0.01）. But there was no significant difference between two groups in SON. Conchlsion These results suggest that AT1 in brain may play an important role in modulating blood pressure of the neuroendocrine regulations, and may be related to the occurrence and development of pregnancy-induced hypertension.
出处
《解剖学研究》
CAS
2009年第1期5-8,共4页
Anatomy Research
基金
南京医科大学科技发展基金(06NMUM004)
关键词
妊高征
血管紧张素Ⅱ
1型受体
下丘脑
孤束核
Pregnancy-induced hypertension symptom
angiotenisn Ⅱ type 1 peceptor （AT1）
Hypothalamus
Nucleus of solitary tract
