摘要
目的探讨肌氨肽苷治疗对急性心肌梗死(AMI)患者近期心血管事件及血管内皮功能的影响。方法将122例急性心肌梗死患者分为肌氨肽苷治疗组62例,常规治疗组60例,对照组30例。对比3个月后两组心血管事件的发生来评价对近期预后的影响,以及检测血浆血浆内皮素(ET)、一氧化氮(NO)以判断血管内皮功能。结果治疗后肌氨肽苷组的ET与治疗前比较呈显著性回降,NO则呈显著性回升。常规治疗组的ET、NO较治疗前有变化但差异无显著性。治疗3个月后再发ACS、恶性心律失常、充血性心功能衰竭例数肌氨酞苷组12例,常规治疗组21例。结论肌氨酞苷治疗AMI有效且能改善近期预后,再发ACS、恶性心律失常以及充血性心衰的发生均能明显减少,并能有效改善血管内皮功能。
Objective To evaluate the effect of muscular amino acids and nucleosides on vascular endothelial function and the prognosis in patients with acute myocardial infarction（MAAN）. Methods 122 patients with acute myocardial infarction were divided into two groups： Muscular amino acids and nucleosides treatment group（ MAAN ,62 cases） , routine treatment group（ RT ,60 cases）, in addition, control group （32 cases）. 3 months later, the effect of short-term prognosis and cardiac accid.ent was compared with it before treatment, and the plasma endothelin（ET）, nitricoxide （NO） were measured to evaluate vascular endothelial function. Results After treatment, ET level was obviously decreased in MAAN, the NO level was increased in MAAN group. But in RT group the changes was no significant;the cases of recurrent ACS, serious arrhythmia, congested heart failure in MAAN was 12, and in RT group was 21 respectively. Conclusion MAAN can significantly decrease out-come of recidivity ACS, serious arrhythmia, congestive heart failure and also can significantly improve vascular endothelial function too.
出处
《中华全科医学》
2009年第3期253-254,共2页
Chinese Journal of General Practice
关键词
肌氨肽苷
急性心肌梗死
心血管事件
血管内皮
Muscular amino acids and nucleosides
Acute myocardial infarction
Cardiovascular events
Vascular endothelia
