摘要
目的研究检测临床患者血浆(1→3)-β-D-葡聚糖的含量,以便对危重病人深部真菌感染早发现、早治疗,降低死亡率。方法应用MB-80微生物动态快速检测系统,并以传统真菌培养方法作平行对照实验,分析比较深部真菌感染组和非深部真菌感染组血浆(1→3)-β-D-葡聚糖的水平。结果16例深部真菌感染组的(1→3)-β-D-葡聚糖水平为51.7±66.5 pg/mL,明显高于正常非深部真菌感染组8.6±25.2 pg/mL(P<0.05),且比传统培养方法快速、准确。结论血浆(1→3)-β-D-葡聚糖的含量检测用于临床诊断深部真菌感染,具有敏感性高、特异性强、快速准确等特点。
Aim This research was carried out to test the level of （1→3）-β-D-glucan in plasma among the patients with severe invasive fungal infection so as to find it earlier, give the patients timely treatment and reduce the death rate. Methods Using MB-80 instrument to examine the level of （1→3）-β-D-glucan in plasma. At the same time, the findings of this new test method were compared with those of traditional fungus culture. Results Patients diagnosed as invasive fungal infection have a higher level of （1→3）-β-D-glucan in plasma than the control group. The infection group＇s value of （1→3）-β-D-D-glucan is 51.7 ± 66. 5 pg/mL while the control group＇s value is 8.6± 25.2 pg/ml （ P value 〈 0. 05 ）. Besides, this new method is more rapid and accurate in testing level of （1→3）-β-D- glucan in plasma than the traditional fungus culture method. Condusion The level of （1→3）-β-D-D-glucan in plasma could be used to diagnose the invasive fungal infection. What＇s more, this new testing method has the characteristics of high sensitivity, specificity, rapidity, accuracy and so on.
出处
《西北大学学报（自然科学版）》
CAS
CSCD
北大核心
2009年第1期83-86,共4页
Journal of Northwest University（Natural Science Edition）
基金
陕西省自然科学基金资助项目(2007K12-02)
