摘要
目的对6-甲基尿嘧啶及其N-取代衍生物的合成方法进行研究和改进。方法用醋酸锌作催化剂，二甲苯作溶剂，使乙酰乙酸乙酯和氨基甲酸乙酯在140℃反应6h，得到6-甲基-2，3-二氢-1，3-噁嗪-2，4-二酮，噁嗪二酮再和氨或N-取代胺，在150～160℃反应2h，合成出了目标产物。结果合成出6-甲基尿嘧啶和6种N-取代-6-甲基尿嘧啶衍生物，用1HNMR和元素分析表征了目标化合物的结构；产率为76．1％～90％。结论该方法原料易得，不用酸性催化剂，条件温和，是合成N-取代尿嘧啶理想方法。
Aim To improve the method for the synthesis of 6-methyluracile and N-substituted derivative. Methods Using zinc acetate as catalyst, xylene as solvent, the reaction of ethyl acetoacetate with ethyl carbamate was processed at 140 ℃ for 6 h to give 6-methyl-2,3-dihydrogen-1,3-oxazine-2,4-dione. Oxazine-dione reacted with a- mine or N-substituted amine at 150 - 160℃ for 2 h to give 6-methyluracile and six N-substituted derivatives. Resuits The yield of the target is 76. 1% - 90 %. The structure of the compounds was confirmed by1H NMR and elementary analysis. Conclusion The methods were mild and available for synthesis of 6-methyluracile and N-substituted derivative without the use of acid catalyst.
出处
《西北大学学报（自然科学版）》
CAS
CSCD
北大核心
2009年第1期63-66,共4页
Journal of Northwest University（Natural Science Edition）
基金
陕西省教育厅产业化培育基金资助项目(03JC01)
