摘要
目的:建立同时测定呋喃西林拉氏糊中水杨酸和呋喃西林含量的方法。方法:采用双波长分光光度法,以水为溶剂,296.6nm为测定波长,314.4nm为参比波长测定其中水杨酸的含量;以375.0nm为测定波长直接测定其中呋喃西林的含量。结果:水杨酸、呋喃西林检测浓度的线性范围分别为10.77～43.08(r=0.999 0)、2.58～10.32μg·mL-1(r=1.000 0);平均回收率分别为99.55%(RSD=0.47%)、100.03%(RSD=0.80%)。结论:本方法操作简便、快速、结果准确,可用于该制剂的质量控制。
OBJECTIVE： To establish a method for the simultaneous determination of the contents of salicylic acid and nitrofural in Fu- La pastes. METHODS： A dual- wavelength spectrophotometry was adopted for the determination of the contents of salicylic acid and nitrofural with water used as solvent. The content of salicylic acid was determined with the detective wavelength set at 296.6 nm and the reference wavelength set at 314.4 nm. The content of the nitrofural was determined directly with the detective wavelength set at 375.0 nm. RESULTS： The linear ranges of salicylic acid and nitrofural were 10.77--43.08μg · mL ^-1 （r = 0.999 0） and 2.58--10.32μg · mL ^-1 （r = 1.000 0）, respectively; and their average recovery rates were 99.55% （RSD =0.47%） and 100.03% （RSD = 0.80%）, respectively. CONCLUSION： The method is simple, rapid and accurate, and suitable for the quality control of Fu La pastes.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第7期542-543,共2页
China Pharmacy
