摘要
目的 :探讨中药加针刺诱发排卵与子宫内膜雌激素受体 (ER)、孕激素受体(PR)含量的关系。方法 :2 9例排卵功能失调患者采用补肾为主的中药加针刺治疗 1～ 3个月。并用免疫组化法测ER和PR ,按PR含量将其分为PR阳性、PR弱阳性两组。结果 :PR阳性组 1 5例 ,合并不孕 1 4例 ,完成治疗 45周期 ,排卵 40周期 ,排卵率 88 89% ,受孕 1 0例 (71 43 % ) ;PR弱阳性组 1 1例 ,合并不孕 9例 ,完成治疗 3 3周期 ,排卵 1 0周期 ,排卵率 3 0 3 0 % ,受孕 2例(2 2 2 2 % )。两组排卵率及受孕率比较 ,有显著性差异 (均P<0 0 1 )。结论 :宫内膜受体缺陷是导致不孕的重要因素之一 ,宫内膜ER、PR阳性患者用中药加针刺治疗可以取得较好的疗效。
Objective: To study the effect of Chinese herbal medicine for replenishing Kidney combined with acupuncture in treating anovulation and infertility, and the relationship between its ovulation inducing effect and endometrial contents of estradiol receptor (ER) and progesterone receptor (PR). Methods: Twenty nine cases were treated with replenishing Kidney drugs combined with acupuncture for 1～3 months. Patients' ER and PR were measured by immunohistochemical method. And patients were classified according to PR content into PR positive group and mild PR positive group. Results: Fifteen cases of PR positive group, completed treatment for 45 cycles, among them, 40 cycles showed ovulation, the ovulation rate being 88.89%. Ten in 14 cases, who complicated with infertility, became pregnant, the pregnant rate being 71.43%. While in 11 cases of PR mild positive group, 9 complicated with infertility, completed treatment for 33 cycle, 10 cycles showed ovulation (30.30%),and pregnant rate 22.22%(2/9).The difference between the two groups was significant (P<0 01). Conclusion: The replenishing Kidney drugs combined with acupuncture treatment could result a good effect in treating infertility due to anovulation, especially on those with high endometrial PR content.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1998年第4期225-226,共2页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
不孕症
无排卵
补肾
针刺疗法
子宫内膜
雌激素
anovulation
infertility
replenishing Kidney drug
acupuncture
endometrium
estradiol receptor
progesterone receptor
