摘要
目的评价99Tcm-甲氧基异丁基异腈(99Tcm-MIBI)乳腺显像对乳腺肿物良恶性鉴别诊断的价值。方法对105例乳腺肿物拟行手术的患者术前1周行乳腺双时相显像,术后行病理组织学检查。结果105例乳腺肿物患者99Tcm-MIBI核素显像阳性68例,阴性37例;67例乳腺癌患者99Tcm-MIBI核素显像阳性61例、阴性6例;38例良性病变中99Tcm-MIBI核素显像阴性31例、阳性7例;99Tcm-MIBI核素显像诊断乳腺癌的灵敏度为91.0%,特异性为81.6%,准确性为87.6%,阳性预测值为89.7%,阴性预测值为83.8%;99Tcm-MIBI双时相显像结果显示乳腺癌组早期相T/N比值(1.58±0.48)明显高于良性病变组(1.21±0.43),t=3.72,P<0.001,乳腺癌组延迟相T/N比值(1.50±0.44)高于良性病变组(1.18±0.36),t=3.47,P<0.05。结论99Tcm-MIBI显像对乳腺癌的诊断及良、恶性病变的鉴别有较高的敏感性、特异性和准确性。
Objective To evaluate the value of ^99Tc^m-MIBI imaging on differentiation and diagnosis of benign and malignant breast lesions. Methods ^99Tc^m-MIBI scintiphoto- graphy was performed in 105 untreated-patients with breast masses in early （30min） and later period（180min） respectively and then the results of pathohistology were detected. Results Of the 105 cases with breast masses,68 patients ^99Tc^m-MIBI images were positive,and 37 images were negative.61cases were positive and 6 cases were false negative in 67 malignant imaging.7cases＇were false posi- tive and 31cases true negative in 38 benign.The sensitivity of ^99Tc^m-MIBI images in diagnosis of breast cancer was 91.0% ,and the specificity was 81.6% ,the positive and the negative predictive values were 89.7% and 83.8% respectively, and the accuracy was 87.6% ;The T/N ratios in 67 patients with breast cancer was higher than that of 38 benign patients in early and later period （ t = 3.72, P 〈 0.01 ; t = 3.47, P 〈 0.05）. Conclusion ^99Tc^m-MIBI imaging provides clinically valuable information on patients with palpable breast masses.^99Tc^m-MIBI imaging has high sensitivity and accuracy in diagnosis of breast cancer and in differentiation between benign and malignant breast lesions.
出处
《宁夏医科大学学报》
2009年第1期50-51,54,共3页
Journal of Ningxia Medical University
基金
宁夏回族自治区卫生厅重点科研项目(200321)
