摘要
目的研究槐定碱对大鼠急性心肌梗死范围的影响。方法结扎左冠状动脉前降支(LAD)制备大鼠急性心肌缺血模型,以丹参和硝酸甘油为对照,观察槐定碱2.5、5和10mg/kg对心肌缺血模型的影响。缺血3h后进行心肌大体标本(TTC)染色以确定心肌梗死范围。结果槐定碱2.5、51、0 mg/kg组均能够缩小缺血心肌梗死范围(P<0.05)。结论槐定碱能够缩小急性心肌缺血损伤引起的心肌梗死范围。
Objective To investigate effect of Sophoridine on the myocardial infarction size （MIS） in mrs with acute myocardial ischemia （AMI） injury. Methods The model was established by ligating the left anterior descending coronary artery （LAD）. Effect of Sophoridine 2.5 mg,/kg,5 mg/kg and 10 mg/kg on the myocardial infarction size （MIS） were observed in rats with AMI and compared with with Danshen and Nitroglycerin. 3 hours after ischemia, myocardial infarction size was determined by triphenyl tetrazohum chloride （TIC） stain. The results were compared with that in AMI group. Results MIS decreased significantly in Sophoridine groups （ P 〈 0.05）. Conclusion Sophoridine had protective effects on acute myocardial ischemia injury induced by LAD occlusion in rats.
出处
《宁夏医科大学学报》
2009年第1期22-23,共2页
Journal of Ningxia Medical University
基金
2007年宁夏回族自治区卫生厅科研项目(W200716)
2008年宁夏医科大学面上项目(XM200801)
