摘要
目的观察转移因子治疗扁平疣患者对其免疫功能的影响及临床疗效。方法60例扁平疣患者随机分为两组：加转移因子治疗组（治疗组）和常规方法治疗组（对照组），每组各30例，观察临床疗效。在治疗前和治疗后应用流式细胞仪检测外周血T淋巴细胞亚群，酶联免疫吸附实验检测血清中白介素10（IL-10）和γ干扰素（INF-γ）的水平，并与20例健康正常人组比较。结果治疗组总有效率高达76．67％，对照组仅为43．33％（Χ^2=5．63，P〈0．05）。扁平疣患者与正常人组比较，CD3^＋、CD4^＋明显低而CD8^＋明显高，CD4^＋／CD8^＋则明显低（P〈0．01）；治疗组患者在治疗后CD3^＋、CD4^＋均明显升高（P〈0．05）而CD8^＋明显降低，CD4^＋／CD8^＋则明显升高（P〈0．01）；对照组在治疗前后无显著性差异。扁平疣患者与正常人组比较，扁平疣患者IL-10高而INF-γ低（P〈0．05），治疗组患者在治疗后IL-10降低而INF-γ升高（P〈0．05），对照组在治疗前后无显著性差异。结论扁平疣患者存在免疫功能异常；转移因子可以提高患者免疫功能，治疗扁平疣临床疗效较好。
Objective To observe the effect of transfer factor on immunity in patients with varruca plana and the clinical effect of treatment. Methods Sixty patients with varruca plana were randomly divided into a treatment group （treated with transfer factor） and a control group （treated with routine therapy）. Before and after the treatment, T-lymphocyte subgroups in peripheral blood of all the patients were determined by flow eytometry and serum levels of interleukin-10 （IL-10）and interferon gamma （INF-γ）were detected by ELISA. The same detections were done to the twenty healthy volunteers as healthy controls. Results Effective rates in the treatment group and control group were 76.67% and 43. 33%, respectively （Χ^2 = 5. 63, P〈 0.05）. Decrease of CD3^＋ cells, CD4^＋ cells, CD4^＋/CD8^＋ ratio and increase of CD8^＋ cells were found in varruca plana group as compared with the healthy controls（P〈0.01）. After the treatment of transfer factor, increase of CD3^＋ cells,CD4^＋ cells （P〈0.05）, CD4^＋ /CD8^＋ ratio （P〈0.01）and decrease of CD8^＋ cells（P〈0.01）were found in the treatment group as compared with those before treatment, while there were no significant difference in the control group before and after the treatment. Higher IL-10 and lower INF -γ in serum were found in varruca plana group as compared with the healthy controls （P〈0.05）. After the treatment of transfer factor,decrease of IL-10 and increase INF-γ in serum （P〈0. 05）were found in the treatment group as compared with those before treatment, while there were no significant difference in control group before and after the treatment. Conclusion The results reveal that immunity is impaired in patients with varruca plana. Transfer factor can enhance the immunity of the patients. Therefore, varruca plana patients treated with transfer factor receive better effects.
出处
《中华医学美学美容杂志》
2009年第1期42-45,共4页
Chinese Journal of Medical Aesthetics and Cosmetology
关键词
扁平疣
免疫功能
转移因子
Varruca plana
Immunity
Transfer factor
