摘要
目的:研究慢性乙型肝炎及乙型肝炎后肝硬化患者外周血淋巴细胞(PBL)CD44v6的表达情况及意义。方法:用流式细胞术分别检测50名健康体检者、30例乙型肝炎病毒(HBV)携带者、60例慢性乙型肝炎患者及60例乙型肝炎后肝硬化患者PBLCD44v6的表达水平。结果:慢性乙型肝炎患者PBLCD44v6表达明显高于正常对照组和HBV携带组(P<0.01);肝炎后肝硬化组明显高于慢性乙型肝炎组(P<0.01);HBV携带组与正常对照组之间的差异也有统计学意义(P<0.01)。结论:CD44v6在慢性乙型肝炎HBV致肝细胞损伤过程中可能起着重要作用。
Objective To study the significance of expression of CD44v6 on peripheral blood lympoeytes in patients with chronic hepatitis B. Methods Expression of C1M4v6 on peripheral blood lymphoeytes were examined with flow - eytometry in 30 HBV carriers, 60 patients with chronic hepatitis B, 60 patients with post - hepatitis B hepatic cirrhosis and 50 controls. Results Peripheral blood lymphocyte CD44v6 expressions in hepatitis B virus carriers were significantly higher than those in controls （ P 〈 0.01 ）. Expression of CD44v6 in patients with chronic hepatitis B were significantly higher than those in HBV carriers （ P 〈 0.01 ）. Expressions in patients with cirrhosis were further significantly higher than those in patients with HBV hepatitis only （ P 〈 0.01 ）. Conclusion CD44v6 might play important roles in the progression of hepatic injury and deterioration of hepatic function in patients with HBV hepatitis.
出处
《放射免疫学杂志》
CAS
2009年第1期72-74,共3页
Journal of Radioimmanology
关键词
慢性乙型肝炎
CD44V6
淋巴细胞
流式细胞术
chronic hepatitis B, CD44v6, peripheral blood lymphocytes （PBL）, flow cytometry
