摘要
本文报告了巯甲丙脯酸对家兔失血性休克的作用。复制家兔失血性休克模型后,将动物随机分为巯甲丙脯酸治疗组和对照组。结果表明:在治疗组,静滴巯甲丙脯酸1mg/kg 及配合输液输血后,平均动脉血压、中心静脉压、肾血流量均见明显回升,肠系膜微循环有显著性改善,1小时接近正常水平;与对照组相比差异有高度显著性意义(p<0.01)。认为巯甲丙脯酸具有良好的抗失血性休克作用。
This paper reports the effect of captopril (SQ14225)on hemorrhagicshock in rabbits.After a hemorrhagic shock model was replicated,the rabbits wererandomly divided into a captopriltreated group (n=13) and a control group(n=13).In the treated group,intravenous drip of captopril (lmg/1kg) was performed withnormal saline (15ml/kg),low molecular dextran (15ml/kg) and blood.An hour later,MABP,CVP and renal blood flow were elevated to nearly normal level and mesentl-eric microcirculation was obviously improved,the difference between the controand the treated group was very significant (p<0.01).The results show that captop-ril is effective against hemorrhagic shock.
出处
《济宁医学院学报》
1990年第3期19-21,共3页
Journal of Jining Medical University
关键词
巯甲丙脯酸
休克
失血性
Captopril
Shock,Hemorrhagic
Rabbits
