摘要
目的探讨老年慢性心力衰竭(CHF)患者血浆脑钠肽前体(NT-proBNP)水平与左室功能的关系及临床意义。方法102例CHF患者按美国心脏病协会(NYHA)分级方法分为心功能Ⅱ、Ⅲ、Ⅳ级3组,18名健康老年人纳入对照组。电化学发光双抗体免疫夹心法测定4组血浆NT-proBNP,二维超声测定左室舒张末期内径(LVEDD),Simpon双平面法测定左室射血分数(LVEF)。结果心衰各组NT-proBNP水平、LVEDD高于对照组,LVEF低于对照组。血浆NT-proBNP水平、LVEF、LVEDD在4组间两两比较均有统计学差异(P<0.05或P<0.01)。NT-proBNP水平与LVEDD呈正相关(r=0.76,P<0.01),而与LVEF呈负相关(r=-0.68,P<0.01)。结论NT-proBNP可以用来评估老年心衰患者的左室功能,是反映心衰的客观指标。
Objective To investigate the relationship between the level of serum Nterminal probrain natriuretic peptide（NTproBNP）and left ventricular function in elderly patients with chronic heart failure（CHF） and the clinical significance. Methods The immunofluscence double Sandwich method was used to detect NTproBNP level in 102 elderly patients with CHF,while left ventricular end diastolic diameter（LVEDD）,left ventricular eject fraction（LVEF） were measured by Simpson.The patients with CHF were devided into 3 groups according to NYHA and 18 healthy elderly subjects were enrolled in control group. Results The level of serum NTproBNP and LVEDD were higher and LVEF was lower in patients with CHF than those in control group （P〈0.05 or P〈0.01）.The increase of NTproBNP levels was closely correlated with the severity of NYHA functional class.NTproBNP levels were positively correlated with LVEDD（r=0.76,P〈0.01） and negatively correlated with LVEF（r=-0.68,P〈0.01）. Conclusions NTproBNP is correlated with the severity of symptoms of CHF, as a reliable laboratory marker in elderly patients with CHF at present.
出处
《实用老年医学》
CAS
2009年第1期42-44,共3页
Practical Geriatrics
基金
南京市医学科技发展项目(ZKM06062)
关键词
心力衰竭
脑钠肽前体
心功能
超声心动描记术
heart failure； brain natriuretic peptide； cardiac function； echocardiography
