摘要
目的:探讨通过序列地测定急性心肌梗死(AMI)患者经皮冠脉介入(PCI)前后血浆BNP浓度,探讨了直接和延迟PCI对AMI患者心功能转归的影响。方法:顺序选入2005-12—2006-11月就诊于河北医科大学第三医院心内科的ST段抬高型心肌梗死(STEMI)患者45名。采用酶联免疫吸附法(ELISA)分别检测入院即时、术后7d和30d时的血浆脑利钠肽(BNP)浓度。结果:直接PCI组和延迟PCI组血浆BNP浓度在术前无显著性差异,PCI术后7d、30d的血浆BNP浓度与治疗前比较均有显著下降(P<0.05),术后30d下降更为显著(P<0.01);两组间比较PCI术后7d(183.4±56.2pg/mL vs 243.7±85.2pg/mLP<0.05)和30d(108.3±36.7pg/mL vs 139.4±76.8pg/mLP<0.05)均有显著性差异,前者均低于后者。结论:AMI患者接受PCI治疗后,血浆BNP浓度逐渐下降,直接PCI较延迟PCI治疗血浆BNP浓度下降显著,直接PCI治疗对住院期间AMI患者心功能的改善优于延迟PCI治疗。
Objective.To investigate the effect of primary and delayed PCI on plasma BNP in patients with AMI by a series measurements of BNP at different time before and after PCI. Methods ：Consecutive 45 patients with STEMI who were hospitalized in cardiovascular department of the Third Hospital of Hebei Medical University from December 2005 to November 2006 were eligible, All samples collected on admission immediately, 7 days and 30 days after PCI were performed by enzyme-linked immunosorbent assay（ELISA）. Results： 1 There was no significant difference of plasma BNP between two groups pre-PCI. 2 Two groups plasma BNP concentration after PCI both decreased compared with that of pre-PCI, there was significant difference on 7 days（P〈0. 05）and the difference was more obvious on 30 days（P〈0. 01）after PCI. BNP remained significant lower in Group A than Group B after PCI 7 days（183.4±56.2pg/mL vs 243.7±85.2pg/mL P〈0. 05） ,more significant difference was showed after PCI 30 days（108.3 ± 36.7pg/mL vs 139.4± 76.8pg/mL P〈0. 05）between two groups. Conclusion： Plasma BNP concentration in patients with AMI was decreased after reperfusion therapy of PCI,but effect of primary and delayed PCI on AMI was distinct,the former was decreased faster and more obviously than the latter, and primary PCI outstripped delayed PCI.
出处
《河北北方学院学报（医学版）》
2009年第1期18-21,共4页
Journal of Hebei North University:Medical Edition
关键词
利钠肽/脑
心肌梗死
心功能
经皮冠脉内介入
Natriurectic Peptide/Brain, Myocardial Infarction, Heart Function, Pereutaneous Coronary Intervention
