摘要
蛋白质组技术由于具有大通量研究蛋白质组成和蛋白质差异的作用,已有研究将其应用于胰腺疾病的相关研究中,并为胰腺癌、急慢性胰腺炎、胰腺纤维瘤等研究提供了新的思路.介绍了蛋白质组样品提取技术、蛋白质组分离技术、蛋白质组分析技术、生物信息学及其在胰腺疾病的差异表达蛋白、诊断标记物、相关疾病鉴别标记物、发病机制、治疗敏感性研究中的应用.
With the characteristics of high quantity and quality of protein analysis, proteomics has been used to research the disease of pancreas and supplies new methods for the study of pancreatic cancer, acute pancreatitis （AP）, chronic pancreatitis, fibrocystic disease of the pancreas. It is reviewed that the techniques of the proteome extraction, separation and analysis and the bioinformatics, but mainly introduces the application of proteomics technique in the pancreas disease of the differential expression protein; biomarkers related with the disease for diagnosis; pathogenesis and evaluation responses of different therapies.
出处
《生命科学研究》
CAS
CSCD
2009年第1期76-81,共6页
Life Science Research
基金
国家自然科学基金资助项目(90409014
30873299)
国家973项目(2005CB523306)
上海市重点学科建设项目(T0302)
上海市教委青年基金项目
关键词
蛋白质组学
技术
胰腺疾病
proteomics
technique
the disease of pancreas
