摘要
以四氢罂粟碱外消旋体为原料,N-乙酰-L-亮氨酸、D-2-(2,4-二氯苯氧基)丙酸、N-乙酰-D-苯丙氨酸,N-乙酰-D-亮氨酸为拆分剂,通过结晶方法,拆分制备R-四氢罂粟碱,R型含量大于98%。通过比较,确定最优的拆分剂为N-乙酰-L-亮氨酸。
Using tetrahydropapaverine as raw material, N - acetyl - L - leucine, D - 2 - （2,4 - dichlorophe- noxy） propionie acid, N- acetyl- D- phenylalanine, N- acetyl- D- leucine as resolution agent, and high optical purity （ 〉98% ） R- tetrahydropapaverine was obtained by Crystallization. By comparison, the optimal resolution agent was N - acetyl - L - leucine.
出处
《化工时刊》
CAS
2009年第2期28-29,共2页
Chemical Industry Times
关键词
四氢罂粟碱
拆分剂
结晶
R-四氢罂粟碱
tetrahydropapaverine resolution agent crystallization R- tetrahydropapaverine
