摘要
目的:通过与短程三联疗法比较,观察香连片联合三联疗法根除十二指肠溃疡患者幽门螺杆菌(Hp)感染的根除率和治疗十二指肠溃疡的疗效。方法:120例经胃镜检查确诊为十二指肠溃疡活动期并经快速尿素酶试验和血清抗Hp抗体(ELASE)或病理学检查确定为Hp阳性的患者分为4组:OACX组(奥美拉唑20mg+阿莫西林1000mg+克拉霉素250mg+香连片5片)、OMCX组(奥美拉唑20mg+甲硝唑400mg+克拉霉素250mg+香连片5片)、OAC组(奥美拉唑20mg+阿莫西林1000mg+克拉霉素250mg)和OMC组(奥美拉唑20mg+甲硝唑400mg+克拉霉素250mg),每日2次,连续7天。然后单独奥美拉唑20 mg,每日1次,连续28天,并于用药结束后第28～56天内作13C-尿素呼气试验判断Hp根除率的效果。同时在用药后第1、2、3、7、21和35天对患者的上腹痛、反酸以及上腹烧灼感等症状进行评估。结果:108例患者完成全部治疗方案,12例失访。Hp根除率检查结果显示OACX组的Hp根除率为92.9%(26/28),OMCX组为85.7%(24/28),OAC组为66.7%(18/27)和OMC组为60.0%(15/25)4组间差异有显著性(P<0.01)。症状改善情况:4组从用药第1天起均能有效改善患者的上腹痛、反酸、上腹烧灼感等症状,但是, OACX组和OMCX组的总得分下降幅度均显著高于OAC和OMC组(P<0.05～0.01)。结论:OACX组和OMCX组对Hp具有相当高的根除率,OACX组和OMCX组方案是适合我国国情的根除Hp行之有效的方案,而且,缓解十二指肠溃疡患者的症状,
Objective： to investigate the Helicobacter Pylori （Hp） eradication by triple therapy associated with Xianglianpian（xlp） and its curative effect on duodenal ulcer （DU） when compared with the one-week triple therapy. Methods： 120 case patients in DU active period confirmed by gastroscopy, also positive in rapid urease test （RUT） and serum anti-Hp antibody （ELASE） or pathological examination, were divided into four groups： OACX group, OMCX group, OACgroup and OMC group. They respectively received treatment with OACX （omeprazole 20mg ＋ amoxicillin 1000mg ＋ clarithromycin 250mg＋xianglianpian 5 tablet）, OMCX （omeprazole 20mg ＋ metronidazole 400rag ＋ clarithromycin 250mg＋xianglianpian 5 tablet）, OAC （omeprazole 20mg ＋ amoxicillin 1000mg ＋ clarithromycin 250mg） and OMC （omeprazole 20mg ＋ metronidazole 400rag ＋ clarithromycin 250mg）. All the groups were provided with triple therapy firstly twice a day for seven days continuously, then provided with single omeprazole 20mg once a day for 28 days respectively. 28-56 days after takeing the medicine, 13C urea breath test was performed to judge the effect of Hp eradication rate. In the first, second, third, seventh, twenty first and thirty fifth day, the symptoms of patients such as epigastric gnawing, burning pain and acidity were evaluated simultaneously. Results： 108 patients accomplished all therapy scheme, with 12 patients not being followed up. The results of checking Hp eradication rate were as follows： OACX group, 92.9%（26/28）; OMCX group, 85.7%（24/28）; OAC group, 66.7%（18/27）and OMC group, 60.0%（15/25）. The distinction between the four groups had significancy （P〈0.01）. As for improvement of symptoms, all of the three groups could improve the symptoms such as epigastric gnawing, burning pain and acidity since the first day, but the descending breadth of total scores of OACX and OMCX was significantly higher than that of the OAC and OMC group （P〈0.05-0.01）. Conclusions： A high
出处
《现代生物医学进展》
CAS
2009年第3期505-507,共3页
Progress in Modern Biomedicine
关键词
十二指肠溃疡
幽门螺杆菌
短程三联疗法
根除
香连片
Duodenum ulcer
Helicobacter pylori
Short triple therapy
Eradication
Xianglianpian
