摘要
目的探讨同时性肝胃双原发癌的临床病理特征。方法复习1例同时性胃混合性碰撞型印戒细胞-神经内分泌癌和原发性肝细胞癌患者的临床资料,进行病理组织学和免疫组化观察并复习相关文献。结果本例及文献报道的23例同时性肝胃双原发癌患者均为男性,年龄64.5±6.7岁,其中18例为胃管状腺癌伴肝细胞癌,5例为肝细胞癌分别伴有胃黏液腺癌、胃肝样腺癌、胃神经内分泌癌、胃弥漫大B细胞性淋巴瘤及胃碰撞型印戒细胞—神经内分泌癌,1例为胃癌伴同时性肝细胞癌和胆管癌。其中17例行双根治术,3年及5年生存率分别为61.5%、41.7%。结论同时性肝胃双原发癌多为胃管状腺癌和肝细胞癌,双根治术能延长患者生存期,临床上应注意与胃癌伴肝转移鉴别。
Purpose To investigate the clinicopathologic features of the synchronous double primary cancer of stomach and liver. Methods The clinical data of a patient with synchronous gastric composite collision signet-ring cell/neuroendocrine carcinoma and primary hepatocellular carcinoma was reviewed. The histopathological and immunohistochemieal features were analyzed and relevant literatures were reviewed. Results The case and other 23 cases reported in literatures were male, average age was 64. 5 ±6. 7 years old. Eighteen of 24 cases were diagnosed as synchronous gastric tubular adenocarcinoma with hepatocellular carcinoma. Five cases with primary bepatocellular carcinoma were accompanied by mucinous adenocarcinoma, hepatoid adenoearcinoma, neuroendocrine carcino- ma, diffuse large B cell lymphoma and composite collision signet-ring cell/neuroendocrine carcinoma in stomach respectively. One case was diagnosed as combined hepatocellular carcinoma and cholangiocarcinoma accompanied by gastric cancer. Seventeen of 24 cases underwent double radical resection, and the 3- and 5-year survival rates of the patients were 61.5% and 41.7% , respectively. Conclusions Most of the synchronous double primary cancer cases are synchronous gastric tubular adenocarciuoma with hepatocellular carcinoma. The double radical resection offers a chance for long-term survival. Double primary cancer should be differentiated from gastric carcinoma accompanied by metastatic hepatic carcinoma clinically.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2008年第6期682-686,共5页
Chinese Journal of Clinical and Experimental Pathology
关键词
胃肿瘤
肝肿瘤
双原发癌
混合癌
碰撞癌
stomach neoplasmas
liver neoplasmas
double primary cancers
collision carcinoma
composite carcinoma
