摘要
目的探讨阿仑膦酸钠（福善美）对绝经后骨质疏松性桡骨远端骨折患者骨密度及骨折愈合的影响。方法对62例绝经后骨质疏松性桡骨远端骨折患者行手法整复固定后，测定健侧桡骨骨密度值，随机分为治疗组（32例）及对照组（30例）。治疗组应用福善美口服70mg，每周1次；钙尔奇-D每天600mg；对照组仅给予钙尔奇D每天600mg治疗。给药12周。治疗过程中密切观察患者骨折愈合时间，并于用药12周后检测患者健侧骨密度值。结果骨折愈合时间治疗组为（9．3±2．5）周，对照组为（13．0±2．8）周，两组差异有统计学意义（t=5．54，P〈0．01）；治疗组患者骨密度治疗前低于治疗后[分别为（0．615±0．075）g／cm。和（0．665±0．085）g／cm^2，t=2．50，P〈0．053，对照组治疗前后[分别为（0．620±0．085）g／cm^2和（0．617±0．075）g／cm^2]则差异无统计学意义（P〉0．05）；两组治疗后骨密度比较，治疗组高于对照组（t=2．46，P〈0．05）。结论福善美治疗骨质疏松性桡骨远端骨折，能促进骨痂早期形成、增加骨密度、缩短外固定时间。
Objective To observe the effects of fosamax on the fracture healing and the bone mineral density （BMD） in postmenopausal women with radius distal osteoporotic fracture （RDOF）. Methods All the 62 patients with RDOF were randomly divided into 2 groups after the fracture was fixed manually. Thirty-two patients in treated group took fosamax 1 tablet （70 rag） per week for 12 weeks and caltrate D 600 mg per day, while the other 30 patients in control group took caltrate D 600 mg per day only. The BMD and the fracture healing time were detected after 12 weeks＇ treatment. Results The fracture healing time was （9.31± 2.50） weeks in treated group and was （13.0 ± 2.8） weeks in control group （t= 5.54,P〈0. 01）. BMD was significantly increased after treatment in treated group [（ 0. 615±0. 075） g/cm^2 vs. （0.665±0.085） g/cm^2,t=2.50,P〈0.05], while there was no obvious change of BMD in control group [（ 0. 620±0. 085） g/cm^2 vs. （0. 617±0. 075） g/cm^2 , P〈0.05]. BMD was higher in treated group than in control group after treatment （t 2.46, P〈 0. 05）. Conclusions Fosamax can promote formation of bony callus, increase BMD and shorten external fixation time of radius distal osteoporotic fracture in postmenopausal women.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2009年第2期149-151,共3页
Chinese Journal of Geriatrics
关键词
桡骨骨折
二膦酸盐类
骨密度
Radius fracture
Diphosphonates
Bone density
