摘要
目的分析术前动脉灌注化疗对大肠癌生物学行为的影响，并探讨术前动脉灌注化疗对肿瘤细胞影响的机制。方法35例大肠癌患者随机分为术前动脉灌注化疗组（20例）和对照组（15例）。术前动脉灌注化疗采用动脉造影技术，经肿瘤营养动脉给予氟尿嘧啶1000mg，表阿霉素60mg，丝裂霉素10mg。全部患者均接受手术治疗，切除标本分别行常规病理检查及免疫组织化学染色（因子相关抗原染色）测定大肠癌组织微血管密度（MVD）。微血管密度计数采用Weidner方法分别计数癌中心、癌黏膜表面及癌旁组织的微血管数。结果术前动脉灌注化疗组大肠癌组织中心、癌黏膜表面及癌旁组织的MVD分别为（40．46±7．06）、（52．27±18．40）和（49．92±8．15）；对照组大肠癌组织中心、癌黏膜表面及癌旁组织的MVD分别为（46．09±12．21）、（73．44±22．06）和（51．94±12．64）。两组之间癌黏膜表面的MVD值差异有统计学意义（P〈0．05），癌旁组织及癌中心组织MVD差异无统计学意义。结论术前动脉灌注化疗可以降低大肠癌组织黏膜表面的微血管密度。
Objective To evaluate the effects of pre-operative intra-arterial infusion chemotherapy on colorectal cancer. Methods 35 patients with colorectal cancer,treated by surgery were divided into two groups randomly. There were 20 patients in group A（pre-operative intra- arterial infusion chemotherapy） and 15 in group B（eontrol）. Arterial contrast technique was used in group A then mitromye in 10mg,5-Fu 1000rag epirubic in 60rag were given through Weidner way. Results Microvessel density in the center, surface of the tumor and adjacent tissue around the tumor were （40. 46 ± 7.06 ）, （ 52.27 ± 18.40 ）, （ 49. 92 ± 8. 15 ） in group A, and （ 46.09 ± 12. 21 ）, （ 73.44 ± 22. 06） , （51.94 ± 12.64） in group B. Microvessel density on the surface in group A was significantly lower than that of group B（ P 〈 0.05 ） , with no significance between the center and the adjacent tissue. Conclusion Pre-operative intraarterial infusion chemotherapy is able to reduce micro-vessel density on the surface of colorectal tumor.
出处
《中国基层医药》
CAS
2008年第12期1950-1951,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
结直肠肿瘤/药物疗法
微血管密度
动脉灌注化疗
Colorectal neoplasms/drug therapy
Micro-vessel density
Arterial infusion chemotherapy
