摘要
目的研究肝硬化失代偿期患者胃肠道功能紊乱的电生理表现及胃肠动力药的疗效。方法用胃电图仪EGG-5D6记录32例失代偿期肝硬化患者和35例健康志愿者餐前餐后胃的电图情况并进行比较;然后对32例肝硬化患者用多潘立酮进行干预后测餐前餐后胃的电图并与其干预前的情况进行比较。结果失代偿期肝硬化患者胃电图幅值较健康志愿者低(P<0.05),异常电节律的发生率高(P<0.05)。进食可以明显增加肝硬化患者和健康志愿者的胃肠电活动,但是对失代偿期肝硬化患者的促进作用较弱,用多潘立酮干预后胃电图幅值在餐前餐后都有明显增加(P<0.05),异常电节律的发生率明显降低(P<0.05)。结论失代偿期肝硬化患者存在胃肠功能紊乱并且进食对胃肠道收缩功能的增幅较健康自愿者小,用多潘立酮等胃肠道动力药可以改善患者的胃肠道功能。
Objective The aim of this research is to explore the gastric electrical activity of patients with decompensated cirrhosis and evaluate the effect of domperidone on them. Methods The electrogastrograms of 32 patients and 35 healthy volunteers were recorded by the model EGG-5D6 electrogastrograph and compared. After treatment with domperidone, preprandial and postprandial electrogastrograms of 32 patients were recorded and compared with electregastrograms before treatment. Results The amplitude of gastric electricity was significantly lower in patients with decompensated cirrhosis in comparison with healthy volunteers （ P 〈 0.05 ）. The amplitude of gastric electricity increased rapidly after eating, but the extent of increase was lower in patients, compared with healthy subjects. After treatment with domperidone, preprandial and post-prandial amplitude of gastric electricity had a significantly increase in patients （P〈0.05 ） , and the incidence rate of abnormal electricity rhythm decreased obviously （P〈0.05）. Conclusion There is gastrointestinal dysfunction in patients with decompensated cirrhosis and the amplitude of gastric electricity increases less than healthy volunteers after eating. Domperidone can improve the gastrointestinal function of patients.
出处
《临床和实验医学杂志》
2009年第2期19-20,共2页
Journal of Clinical and Experimental Medicine
关键词
肝硬化
胃肠功能紊乱
胃电图
多潘立酮
Liver cirrhosis
Gastrointestinal dysfunction
Electrogastrogram
Domperidone
