摘要
[目的]研究中药复方熊胆解酒汁对小鼠醉酒及其肝胃损伤的影响。[方法]选用乙醇直接灌胃法建立小鼠致病模型,分别进行致醉、防醉、解酒,采用药理学方法、生物化学法对血清、肝和胃中ADH活性及血清中GPT活性进行测定。[结果]结果表明,小鼠最适致醉量为0.16 m l/10 g;中药复方熊胆解酒汁对醉酒能起到预防作用,且使醉酒小鼠翻正反射恢复的时间缩短,并能使血清ADH、GPT活性及肝、胃组织中ADH活性恢复正常。[结论]中药复方熊胆解酒汁有较好的解酒和预防醉酒作用,对小鼠的酒精性肝胃损伤亦有较好的防护作用。
[ Objective ] The purpose was to study the influence of Chinese traditional medicine with bile on alcoholic liver, stomach and alcoholic intoxication disease in mice. [ Method] The mouse pathogenesis model was established by filling ethyl alcohol law directly garage, determining the activity of ADH in blood-serum, liver, stomach and the activity of GPT in blood-serum by pharmacology method and biological chemistry method. [ Result] The results indicated that the amount of optimal ebrietas of mouse was 0.16 ml/10 g ; the Chinese traditional medicine with bile could prevent from ebrietas, decrease the time of body-righting reflex of mouse and recover the activity of b, DH in blood-serum, liver, stomach and the activity of GPT in blood-serum. [ Conclusion] The Chinese traditional medicine with bile has better effects on ebrietas relief and preventing from ebrietas, and it also has better effects on preventing from hepatic injury by alcohol.
出处
《安徽农业科学》
CAS
北大核心
2009年第2期608-610,共3页
Journal of Anhui Agricultural Sciences
关键词
中药复方
熊胆汁
解酒
肝胃损伤
Chinese traditional medicine
Bile
Alleviating a hangover
Hepatogastric damage
